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Journal of Data and Information Science  2018, Vol. 3 Issue (2): 38-61    DOI: 10.2478/jdis-2018-0008
Research Paper     
A Study of Methods to Identify Industry-University-Research Institution Cooperation Partners based on Innovation Chain Theory
Haiyun Xu 1(), Chao Wang 1,3, Kun Dong1,3, Rui Luo1,3, Zenghui Yue4, Hongshen Pang5
1Chengdu Documentation and Information Center, Chinese Academy of Sciences, Chengdu 610041, China
2Institute of Scientific and Technical Information of China, Beijing 100038, China
3University of Chinese Academy of Sciences, Beijing 101407, China
4School of Medical Information Engineering, Jining Medical University, Rizhao 276826, China
5Library, Shenzhen University, Shenzhen 518060, China
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Abstract  

Purpose: This study aims at identifying potential industry-university-research collaboration (IURC) partners effectively and analyzes the conditions and dynamics in the IURC process based on innovation chain theory.Design/methodology/approach: The method utilizes multisource data, combining bibliometric and econometrics analyses to capture the core network of the existing collaboration networks and institution competitiveness in the innovation chain. Furthermore, a new identification method is constructed that takes into account the law of scientific research cooperation and economic factors.Findings: Empirical analysis of the genetic engineering vaccine field shows that through the distribution characteristics of creative technologies from different institutions, the analysis based on the innovation chain can identify the more complementary capacities among organizations.Research limitations: In this study, the overall approach is shaped by the theoretical concept of an innovation chain, a linear innovation model with specific types or stages of innovation activities in each phase of the chain, and may, thus, overlook important feedback mechanisms in the innovation process.Practical implications: Industry-university-research institution collaborations are extremely important in promoting the dissemination of innovative knowledge, enhancing the quality of innovation products, and facilitating the transformation of scientific achievements.Originality/value: Compared to previous studies, this study emulates the real conditions of IURC. Thus, the rule of technological innovation can be better revealed, the potential partners of IURC can be identified more readily, and the conclusion has more value.



Key wordsInstitutions collaboration      Collaboration network      Innovation chain      Industrial chain      Industry-university-research institutions     
Received: 03 May 2018      Published: 14 June 2018
Cite this article:

Haiyun Xu, Chao Wang, Kun Dong, Rui Luo, Zenghui Yue, Hongshen Pang . A Study of Methods to Identify Industry-University-Research Institution Cooperation Partners based on Innovation Chain Theory. Journal of Data and Information Science, 2018, 3(2): 38-61.

URL:

http://manu47.magtech.com.cn/Jwk3_jdis/10.2478/jdis-2018-0008     OR     http://manu47.magtech.com.cn/Jwk3_jdis/Y2018/V3/I2/38

Figure 1. Model of the innovation chain
First-level indexes Innovation target Category Participate subjects Second-level indexes
Basic research Problem→Theory technology University, R& D institutes research papers
Application research Theory→Appliaction technology University, R&D institutes patents
Transfer and Transformation Appliaction→Production technology University, R&D institutes, enterprises technological achievements amount
Commercialization Production→Marketing economic enterprises goods amount
Industrialization Marketing→Industry economic Production subject, sales subject industrial scale
Table 1 Evaluation indexes of institutional competitiveness based on innovation chain.
Figure 2. K core network of GEV cooperation-based publications in China domestic.
Figure 3. Two mode network of GEV patent applications and technology-effect.
No. institution Province Number of papers citations Cited amount of average article Number
of CNCI
1 Chinese Academy of Sciences Beijing 26 240 9.23 0.96
2 Chinese Academy of Agricultural Sciences Beijing 25 219 8.76 0.87
3 Chinese Academy of Military Medical Sciences Beijing 12 124 10.33 0.69
4 The Fourth Military Medical University Shaanxi 12 68 5.67 0.39
5 Huazhong University of Science and Technology Hubei 10 79 7.90 0.48
6 Shanghai Jiao Tong University Shanghai 9 91 10.11 0.41
7 Zhejiang University Zhejiang 9 67 7.44 0.93
8 Shanghai Institutes for Biological Sciences Shanghai 8 109 13.63 1.07
9 Sichuan University Sichuan 8 37 4.63 0.36
10 Peking University Beijing 7 52 7.43 0.52
11 The Second Military Medical University Shanghai 7 42 6.00 0.71
12 Huazhong Agricultural University Hubei 5 58 11.60 0.73
13 China Medical University Liaoning 5 38 7.60 0.73
14 South China Agricultural University Guangdong 4 51 12.75 1.53
15 Jilin Agricultural University Jilin 4 47 11.75 1.45
16 Central South University Hunan 4 42 10.50 0.6
17 China Agricultural University Beijing 3 46 15.33 0.7
18 Chongqing Medical University Chongqing 3 38 12.67 0.49
19 The National Center for Nanoscience and Technology of China Beijing 1 54 54.00 6.23
Table 2 Publication of SCI papers of domestic GEV by the amount of top19 institutions.
No. Patent agencies Province Number of Patents
1 Fudan University SH 51
2 Third Military Medical University CQ 45
3 Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences GS 39
4 Harbin Veterinary Research Institute,CAAS HL 29
5 Society for Microbiology of Military Medical College BJ 21
6 Huazhong Agricultural University HB 21
7 Nanjing Agricultural University JS 19
8 The Fourth Military Medical University SN 18
9 Aventis Pasteur Company GD 17
10 Institute of Basic Medical Sciences, Academy of Military Medical Sciences BJ 17
11 Jiangsu Academy of Agricultural Sciences JS 17
12 Beijing Kaiyin Biological Technology Co., Ltd. BJ 16
13 Jilin University JL 16
14 The Second Military Medical University SH 16
15 Sichuan Agricultural University SC 16
16 Institute of medical biology of Chinese Academy of Sciences BJ 13
17 Merial Co., Ltd. JX 13
18 Pulaike Biological Engineering Co., Ltd. HN 13
19 Shanghai Human Genome Research Center SH 13
20 South China Agricultural University GD 13
21 Wuhan University HB 12
22 Institute of Microbiology, Chinese Academy of Sciences BJ 11
23 China Agricultural University BJ 11
24 Xiamen University FJ 11
25 Zhejiang University ZJ 11
26 Institute of Medical Biotechnology of Chinese Academy of Medical Sciences BJ 10
27 Yuanlun Biotechnology Co., Ltd. CQ 10
28 Center for Parasitic Diseases Control and Prevention SH 10
29 Institute of Military Veterinary Medicine, Academy of Military Medical Sciences JL 10
30 Shanghai Veterinary Research Institute, CAAS SH 10
31 Zhongshan University GD 10
Table 3 Major GEV patents owners in domestic China (institutions have more than 10 patents).
No. Manufacturers Genetically Engineered Vaccine Province
1 Beijing Tiantan Biological Products Co., Ltd. Recombinant Hepatitis B Vaccine (Saccharomyces cerevisiae) Beijing
2 Shenzhen Kangtai Biological Products Co., Ltd. Recombinant Hepatitis B Vaccine (Saccharomyces cerevisiae) Guangdong
3 Hualan Biolocical Engineering, Inc. Recombinant Hepatitis B Vaccine
(Hansenula polymorpha)
Henan
4 Dalian Hissen Bio-pharm.Co.,Ltd. Recombinant Hepatitis B Vaccine
(Hansenula polymorpha)
Liaoning
5 Beijing Waldorf Shield Biotechnology Co., Ltd. Recombinant Hepatitis B Vaccine
(CHO cell)
Beijing
6 Lanzhou Institute of Biological Products Co., Ltd. Recombinant Hepatitis B Vaccine
(CHO cell)
Gansu
7 NCPC GeneTech Biotechnology Development Co., Ltd. Recombinant Hepatitis B Vaccine
(CHO cell)
Hebei
8 Wuhan Institute of Biological Products Research Co., Ltd. Recombinant Hepatitis B Vaccine
(CHO cell)
Hubei
9 Xiamen Innovax Biotech Co., Ltd. Recombinant Hepatitis E Vaccine (Escherichia coli) Fujian
10 Shanghai United Cell Biotechnology Co., Ltd. Recombinant B subunit / bacterial cholera vaccine (enteric-coated capsule) Shanghai
Table 4 GEV types in domestic China.
Vaccine manufacturer Number of genetically engineered vaccine patents Number of genetically engineered vaccine
Liaoning Chengda Co., Ltd. 2 0
Liaoning Yisheng BioPharma Co., Ltd. 3 0
Xiamen Innovax Biotech Co., Ltd. 3 1
Changchun BCHT Biotechnology Co. 2 0
Table 5 GEV Production of enterprise with relevant patents.
No. Vaccine manufacturer Genetically Engineered Vaccine Proportion
of scale
Region (Country)
1 Shenzhen Kangtai Biological Products Co., Ltd. Recombinant Hepatitis B Vaccine (Saccharomyces cerevisiae) 33.7% Guangdong
2 Beijing Tiantan Biological Products Co., Ltd. Recombinant Hepatitis B Vaccine (Saccharomyces cerevisiae) 24.3% Beijing
3 Dalian Hissen Bio-pharm.Co., Ltd. Recombinant Hepatitis B Vaccine
(Hansenula polymorpha)
19.7% Liaoning
4 NCPC GeneTech Biotechnology Development Co., Ltd. Recombinant Hepatitis B Vaccine
(CHO cell)
12.7% Hebei
5 Glaxo Smith Kline Recombinant Hepatitis B Vaccine (Saccharomyces cerevisiae) 3.9% Belgium
6 Hualan Biolocical Engineering, Inc. Recombinant Hepatitis B Vaccine
(Hansenula polymorpha)
2.5% Hennan
7 Shanghai United Cell Biotechnology Co., Ltd. Recombinant B subunit / bacterial cholera vaccine (enteric-coated capsule) 1.8 Shanghai
8 Beijing Waldorf Shield Biotechnology Co., Ltd. Recombinant Hepatitis B Vaccine
(CHO cell)
0.9 Beijing
9 Berna Biotech AG Recombinant Hepatitis B Vaccine
(Hansenula polymorpha)
0.4 Switzerland
10 Xiamen Innovax Biotech Co., Ltd. Recombinant Hepatitis E Vaccine (Escherichia coli) 0.1 Fujian
Table 6 Total proportion of GEV commercialization scale in domestic China (2007-2015).
Basic research Applied research Transfer and transformation Commercialization and industrialization
Research institutes Research institutes enterprise Enterprise
Agricultural University Agricultural University N/A N/A
comprehensive research university comprehensive research university N/A N/A
N/A enterprise N/A N/A
Table 7 Category types of IURC in GEV innovation chain in domestic China.
Region Basic Research Institute Applied Research Institute Commercialization and industrialization organization
Guangdong South China Agricultural University Aventis Pasteur Company
South China Agricultural University
Zhongshan University
Shenzhen Kangtai Biological Products Co., Ltd.
Beijing Chinese Academy of Sciences
Academy of Military Medical Sciences
Chinese Academy of Agricultural Sciences
Peking University
The National Center for Nanoscience and Technology, Chinese Academy of Sciences
Institute of Microbiology of Military Medical College
Institute of Basic Medical Sciences, Military Medical College
Beijing Kaiyin Biological Technology Co., Ltd.
Institute of medical biology of Chinese Academy of Sciences
Institute of Microbiology, Chinese Academy of Sciences
China Agricultural University
Institute of Medical Biotechnology of Chinese Academy of Medical Sciences
Beijing Tiantan Biological Products Co., Ltd.
Beijing Waldorf Shield Biotechnology Co., Ltd.
Liaoning China Medical University N/A Dalian Hissen Bio-pharm. Co., Ltd.
Heibei N/A N/A NCPC GeneTech Biotechnology Development Co., Ltd.
Henan N/A Pulaike Biological Engineering Co., Ltd. Hualan Biolocical Engineering, Inc.
Shanghai Shanghai Jiao Tong University
Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences
Fudan University
The Second Military Medical University
Shanghai Human Genome Research Center
Center for Parasitic Diseases Control and Prevention
Shanghai United Cell Biotechnology Co., Ltd.
The Second Military Medical University Shanghai Veterinary Research Institute, Chinese Academy of Agricultural Sciences
Fujian N/A Xiamen University Xiamen Innovax Biotech Co., Ltd.
Table 8 The spatial distribution of GEV institutions in domestic China.
Genetically Engineered Vaccine Vaccine manufacturer
Recombinant Hepatitis B Vaccine (Saccharomyces cerevisiae) Shenzhen Kangtai Biological Products Co., Ltd., Beijing Tiantan Biological Products Co., Ltd., Glaxo Smith Kline
Recombinant Hepatitis B Vaccine
(Hansenula polymorpha)
Hualan Biolocical Engineering, Inc., Dalian Hissen Bio-pharm. Co., Ltd., Berna Biotech AG
Recombinant Hepatitis B Vaccine (CHO cell) NCPC GeneTech Biotechnology Development Co., Ltd., Beijing Waldorf Shield Biotechnology Co., Ltd.
Recombinant B subunit / bacterial cholera vaccine (enteric-coated capsule) Shanghai United Cell Biotechnology Co., Ltd.
Recombinant hepatitis E vaccine (Escherichia coli) Xiamen Innovax Biotech Co., Ltd.
Table 9 Types of vaccine production enterprises in domestic China.
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